Medical disclaimer

This site is an educational reference about methylene blue. It is not medical advice, it does not create a clinician relationship, and it sells no products. Methylene blue is FDA-approved only as an intravenous drug (ProvayBlue) for methemoglobinemia. Oral 'nootropic' methylene blue is not an FDA-approved product or use. The FDA-approved label carries a boxed warning: combined with serotonergic drugs (including SSRIs, SNRIs, and MAOIs) or opioids, methylene blue can cause serious or fatal serotonin syndrome, and it is contraindicated in G6PD deficiency. If you develop agitation, confusion, fever, sweating, fast heart rate, muscle rigidity or jerking, or seizures after methylene blue exposure, especially alongside an antidepressant or opioid, seek emergency care immediately. Never start, stop, or combine medications based on anything you read here; bring this site's citations to a clinician instead.