T-01
mg/kg dose visualizer
Published per-kilogram figures from the literature scaled to your entered weight, species labeled on every row.
Shows every dose actually used in the human studies this site cites, by indication, converted between total mg and mg/kg for a user-entered body weight, and plots them against the FDA label's toxicity bands and the rodent U-shape. It answers 'what have humans actually been given, in studies, and where does harm start' without prescribing anything.
The U-shaped curve is rat data. The human bands are label toxicity data. Nothing on this chart is a human dosing recommendation; no human cognitive dose-response has ever been mapped.
Published figures scaled to 70 kg
1 mg/kg over 5-30 min; label maximum 2 doses; renal impairment single dose. Hospital emergency, monitored.
1.5 mg/kg single dose. ICU, monitored.
280 mg once (about 4 mg/kg at 70 kg), USP grade. Research, single dose only.
260 mg immediately after therapy sessions. Research, post-session dosing.
195 mg/day (2017) and 300 mg/day vs 15 mg/day (1986). Research, psychiatric supervision.
69, 138, or 228 mg/day MTC (methylthioninium chloride); best signal at 138 mg/day; exploratory only. Research.
Hypotension, wheezing, reduced oxygenation reported.
Paradoxical methemoglobinemia (up to 7%), chest pain, tremor, confusion, staining; effects 2-12 h.
Severe intravascular hemolysis, hyperbilirubinemia, death.
Improved memory retention; increased brain cytochrome c oxidation.
Improved habituation and object recognition; extinction retention (5-day dosing).
No behavioral difference from saline on locomotion or feeding.
Reduced running-wheel behavior.
Reduced running-wheel behavior.
Scaled mass = published mg/kg x your entered weight. Fixed-dose study rows run the same arithmetic in reverse: mg/kg = the published total dose / your weight. Scaling arithmetic does not transfer evidence between species; dose selection for humans is a clinician's call, not a calculation.
Worked example
Example: at 70 kg, the approved methemoglobinemia dose (1 mg/kg IV) is 70 mg, given once, maximum twice, in a hospital. The single-dose cognition trial gave 280 mg oral, which is 4.0 mg/kg at that same weight, one time, under research supervision. The label documents adverse effects from single doses of 3 mg/kg (210 mg at 70 kg). The gap between 'studied once' and 'harmful' is narrow; that is the point of the chart.
Step by step
- Enter body weight and unit.
- Read each study row converted to your weight.
- Compare study doses against the label hazard bands.
- Open a row's citation to read the study before drawing conclusions.
Doses used in human studies, one line each
| # | Indication | Route | Dose as studied | Salt | Setting | Source |
|---|---|---|---|---|---|---|
| D1 | Acquired methemoglobinemia (FDA-approved use) | IV | 1 mg/kg over 5-30 min; label maximum 2 doses; renal impairment single dose | methylene blue (ProvayBlue) | Hospital emergency, monitored | source |
| D2 | Vasoplegic syndrome after cardiac surgery (off-label, randomized study) | IV | 1.5 mg/kg single dose | methylene blue | ICU, monitored | source |
| D3 | Septic shock adjunct (off-label, RCT) | IV | Protocolized IV dosing started within 24 h of shock onset | methylene blue | ICU, monitored | source |
| D4 | Cognition imaging trial, healthy adults (single dose) | oral | 280 mg once (about 4 mg/kg at 70 kg), USP grade | methylene blue USP | Research, single dose only | source |
| D5 | Fear-extinction augmentation (claustrophobia; PTSD) | oral | 260 mg immediately after therapy sessions | methylene blue | Research, post-session dosing | source |
| D6 | Bipolar disorder adjunct (crossover trials) | oral | 195 mg/day (2017) and 300 mg/day vs 15 mg/day (1986) | methylene blue | Research, psychiatric supervision | source |
| D7 | Alzheimer's phase 2 (different program, same molecule) | oral | 69, 138, or 228 mg/day MTC; best signal at 138 mg/day; exploratory only | methylthioninium chloride (MTC) | Research | source |
| D8 | Dementia phase 3s (MODIFIED SALTS, not methylene blue mg) | oral | LMTM 150-250 mg/day (negative primaries); HMTM 8-16 mg/day (LUCIDITY, primary not demonstrated at 52 wk) | LMTM / HMTM (NOT interchangeable with methylene blue) | Research | source |
Frequently asked questions
Why does this tool not recommend a dose?
Because none exists to recommend. No trial has established a human dose for any wellness use; the tool shows what studies used and where the label documents harm.
Why are the dementia doses grayed out?
Those trials used chemically modified salts (LMTM, HMTM). Their milligrams are not methylene blue milligrams and cannot be converted.
Is the U-shaped curve human data?
No. The curve is rat data and is labeled rat. The human data on the chart are the label's toxicity bands.
Why is there no reconstitution calculator on this site?
Reconstitution math is for injectable research vials. Methylene blue's wellness form is oral and its approved form is a pre-mixed hospital IV solution, so a reconstitution tool would be the wrong tool for this compound. The suite instead screens interactions, shows studied doses, and checks material grade.
Can these tools tell me a safe dose?
No. No human wellness dose has ever been established, and the label documents harm starting at single doses of 3 mg/kg. The visualizer shows studied doses and hazard bands; the decision belongs with a clinician.
Tools: educational calculators and references only.